What is bone metastasis?
In healthy humans, there is a balance between bone formation and break-down. This balance is often upset when people develop cancer.
In Germany, almost 300,000 people develop different types of cancer every year. Bone metastasis occurs more frequently in some types of malignant tumours and less commonly in others.
As the cancer progresses, cancer cells often spread to the bones quite early on. What are the causes and risks of bone metastasis?
In metastasis, cancer cells can spread to the bones. Bone metastasis originates from mutated cells of other tissue which have spread to the bones. Their out-of-control growth disturbs the natural balance between bone formation and break-down, and the bones’ function. Most patients with bone metastasis suffer from severe bone pain.
Even after minor accidents such as falls or bumps pathological fractures (bone breaks) can occur. Therefore it is very important that patients are particularly careful.
Generally, bone metastasis is diagnosed with a radiological exam. X-rays are used as initial examination and to check on the progression of the disease.
Other radiological techniques that may be used include:
- Computer tomography
- Magnetic resonance imaging
- Bone scan (sceletal scintigraphy)
- Bone scan
A bone scan is a particular type of radiological diagnosis. Small amounts of a radioactively marked substance are injected into a vein. For a short time, the substance accumulates in those bone areas where there is increased activity. Those areas can then be made visible.
Bone biopsy
A bone-marrow biopsy allows for a precise examination of the bone tissue, mineralisation and the bone cells.
Aim of the treatment is to stabilise the bone, prevent fractures and provide relief for bone pain.
Different therapy methods can be used:
Surgery
In case of an imminent or actual break the bone needs to be stabilised with an operation.
Radiationtherapy
The cancer cells are destroyed or their growth is inhibited by high-energy x-rays. This type of treatment is particularly indicated if there is evidence of bone metastasis in only a limited region.
Chemotherapy
This treatment is always used when cancer cells are present throughout the body, including the bones. They are destroyed with the help of medicinal products.
Bisphosphonate treatment
The use of bisphosphonate is a proven method for preventing bone fractures as a result of bone metastasis. These substances accumulate at the bone and counteract bone degeneration caused by bone metastasis.
Cookie-Settings
We use technically necessary cookies for the operation of the website. Other cookies are only set with your consent. We use these to statistically analyse the use of the website (location, time, end device, referrer URL). We also share information about the use of the website with our provider Google LLC. We have also integrated videos into our website via the provider Vimeo, a video hosting platform. The service provider is Vimeo Inc. Both providers may combine this information with other data. Your data may also be transferred to the USA. The USA (and other non-EEA countries) do not offer a level of data protection comparable to the EU; for example, government agencies can access data without any reason. However, both Google LLC. and Vimeo Inc. are committed to data protection-compliant processing with the EU standard contractual clauses.
You can revoke your consent to cookies and data transfer at any time with effect for the future. You can find more information in our privacy policy.
Necessary cookies
These cookies help making a website usable by enabling basic functions like page navigation and access to secure areas of the website. The website cannot function properly without these cookies.
Statistics cookies
These cookies help website owners to understand how visitors interact with websites by collecting and reporting information anonymously. With this information we can constantly improve the experience we offer on our website.
Marketing cookies
These cookies are used to track visitors across websites. The intention is to display ads that are relevant and engaging for the individual user and thereby more valuable for publishers and third party advertisers.